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KMID : 0362420130510020082
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Journal of Korean Academy of Prosthodontics
2013 Volume.51 No. 2 p.82 ~ p.89
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Combined effects of rhBMP-2 and rhVEGF coated onto implants on osseointegration: pilot study
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Huh Jung-Bo
Yun Mi-Jung
Jeong Chang-Mo
Shin Sang-Wan
Jeon Young-Chan
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Abstract
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PURPOSE: The present study is aimed to evaluate the combined effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) and recombinant human vascular endothelial growth factor (rhVEGF) coated onto anodized implants on osseointeration.
MATERIALS AND METHODS: Six New Zealand white rabbit were used in this study. Each animal received 4 implants that were either coated with rhBMP-2 and rhVEGF (Study group) or anodized implant (Control group) in both tibia. This was performed using a randomized split-mouth design. A total 24 implants were used. The implant stability quotient (ISQ) value using resonance frequency analyser and removal torque (RTQ) measurement were investigated at 2 and 8 weeks. The t-test was used for statistical analysis (α=.05).
RESULTS: Control and study group showed good osseointegration at 8 weeks. The ISQ and RTQ values of study group were significant compared with the control group at 8 weeks (P<.05). However, No statistical significance was observed at 2 weeks (P>.05).
CONCLUSION: It was concluded that rhBMP-2 with rhVEGF coated onto anodized implants can induce better osseointegration at late healing period.
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KEYWORD
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rhBMP-2, rhVEGF, Implant stability quotient, Removal torque, Osseointegration
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